Ερευνητές στο Ηνωμένο Βασίλειο έχουν σταματήσει πρώιμα το σκέλος της δοκιμής τους στο Covid-19 που περιλαμβάνει το φάρμακο υδροξυχλωροκίνη. Η δοκιμή Recovery, μια μεγάλη δοκιμή που εδρεύει στο Ηνωμένο Βασίλειο και διερευνά πιθανές θεραπείες κορωνοϊού, σταμάτησε να συμπεριλαμβάνει την υδροξυχλωροκίνη στη μελέτη της, επειδή δεν υπάρχει «ένδειξη οφέλους», ανακοίνωσαν οι ερευνητές την Παρασκευή. Τα υπόλοιπα σκέλη της μελέτης, στην οποία συμμετέχουν περισσότεροι από 11.000 ασθενείς από 175 νοσοκομεία σε ολόκληρο το Ηνωμένο Βασίλειο, θα συνεχιστούν.
Article:
Disastrous UK RECOVERY study stops hydroxychloroquine (HCQ) for COVID-19: more than 1100 deaths question ethics and safety overall
6 June 2020. Related: Early access, COVID-19: INVESTIGATIONAL DRUGS, COVID-19.
Simon Collins, HIV i-Base
On 5 June 2020, the large randomised RECOVERY study announced that hydroxychloroquine (HCQ) will no longer be used to treat COVID-19. [1]
The results show that hundreds of people died – both taking HCQ and in the comparison group receiving no investigational drugs – and yet the study was only closed because of a safety request by the UK Medicines and Healthcare products Regulatory Agency (MHRA).
This very large study – with more than 11,000 participants – should have been looking for early signals that experimental treatment might be effective. Instead, the results announced yesterday call for an urgent analysis of other ongoing arms plus immediate use of drugs that are now known to be effective.
The press release states that people receiving HCQ did no better than people who were given no additional drugs – also called the standard of care. Actually, it is not that HCQ didn’t make enough difference for the results to be significantly better. It looks like people taking HCQ did worse than adding nothing, at least numerically. It is very worrying that this analysis was only carried out because of a request by the MHRA.
Επιμέλεια: Κατερίνα Αντωνίου, Αν.Καθηγήτρια Πνευμονολογίας Πανεπιστημίου Κρήτης, Υπεύθυνη Ιατρείων Σοβαρού Άσθματος-Διάμεσης Ίνωσης ΠΑΓΝΗ (Πνευμονολογική Κλινική ΠΑΓΝΗ)
